ERC Consolidator Grant · 2024
Actuation spectroscopy as a new label-free tool to study protein properties in real time
Proteins mediate all cellular functions from cell division, metabolism, and transport to programmable cell death. Studying proteins and their structure-dynamics-function relationship is of paramount importance to understand life and to fight disease. The past decade has witnessed the emergence of revolutionary interferometric scattering (iSCAT) microscopy, which enables optical single-molecule protein imaging, free from laborious fluorescent labeling and chemical tethering. iSCAT paves the way to the long-sought label-free interrogation of single protein molecules. However, this new approach is fundamentally blind to protein conformational dynamics. In ProAct I plan to endow iSCAT…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.