Mathelié-Guinlet Lab

Research focus

ERC Starting Grant · 2024

Physical and molecular underpinnings of the multifunctionality of bacterial peptide assemblies

An important challenge in biophysics is to understand the complex biological functions emerging from the physico-chemical properties of simple building blocks. Showcasing this challenging question is the multiple functions achieved by the phenol soluble modulins (PSMs) peptides from Staphylococcus aureus, able to self-assemble into amyloid structures, and underlying S. aureus pathogenicity. Over the past decade, the intrinsic capacity to form fibrils in vitro has been directly correlated with the peptide biological activities in vivo. This traditional focus severely limits our understanding of the role of more complex intermediate structures and dynamic interactions with the encountered…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.