Karedla Lab

University of Oxford

- · United Kingdom

ERC-funded
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ERC Starting Grant · 2024

Metal-Induced Energy Transfer based Electrometry and Nanometry: Dissecting Electrostatic Phenomena in Biological Processes

Almost all biological processes, involving molecular trafficking, signal-transduction, cell-to-cell interactions, hinge on precisely orchestrated electrostatic interactions, arising from electrical charges on biomolecules and membranes. Yet, our understanding of the role of electrostatics in these fundamental processes remains elusive due to the absence of quantitative methods to measure the electrical charges of biomolecules and to map the surface charge distribution of membranes. This challenge is further compounded by the requirement of capturing molecular and membrane dynamics that take place at the nanometre length scales and nano- to sub-millisecond time scales. The overall objective…

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