ERC Starting Grant · 2024
Multiscale modelling of aberrant phase transitions in biocondensates
The spatiotemporal organization of the cell material represents one of the great wonders in physics, chemistry and biology. Compartmentalization plays a key role in such precise molecular coordination and enables cellular function. Over the past decade, transformative experiments have revealed that most intracellular compartments are not enclosed by membranes, but instead they are dynamical assemblies, termed condensates, and thought to occur via liquid-liquid phase separation of biomolecules. Nevertheless, the misregulation of these condensates—mostly formed by proteins and nucleic acids—can give rise to deleterious solid-like aggregates, which are associated with the proliferation of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.