ERC Consolidator Grant · 2025
Controlling Reactive Intermediates in Biocatalysis through Computational Design Tools
Enzymes are nature’s most efficient catalysts, enabling complex reactions with remarkable speed and selectivity. However, their scope is limited by evolutionary pressures, restricting their utility in synthetic and industrial applications. While enzyme engineering has achieved significant advancements, major challenges remain. Directed evolution has been transformative, but it is labor-intensive and relies on suitable starting scaffolds. Computational enzyme design is promising complementary strategy, however, its potential remains largely unrealized as designed enzymes often require extensive laboratory evolution, underscoring critical gaps in our understanding of enzyme catalysis. This…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.