Kuzhelev Lab

University of Frankfurt

Hessen (DE7) · Germany

ERC-funded
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ERC Starting Grant · 2025

Nanoliter-Scale NMR of Biomolecule Solutions using Dynamic Nuclear Polarization

Dynamic nuclear polarization (DNP) is an exciting and rapidly developing field in magnetic resonance, with solid-state and dissolution DNP techniques emerging as powerful tools across various applications, ranging from materials science to medicine. However, direct DNP in solutions still suffers from a lack of general applicability to macromolecules. The LiquidStateDNP project aims to establish DNP spectroscopy in the liquid state as an innovative tool for chemistry and biology, enabling the analysis of biomacromolecules with small sample volumes as low as a few hundred nanoliters – an achievement beyond the capabilities of traditional NMR techniques. This research will focus on using the…

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