ERC Consolidator Grant · 2017
Multi-scale mechanics of dynamic leukocyte adhesion
Leukocytes, white blood cells, patrol the vascular wall of our vessels in search of sites of inflammation. In the so-called leukocyte adhesion cascade, leukocytes flowing at high velocities (up to mm/s) impact the vessel wall, roll at µm/s, and finally migrate at nm/s to the site of inflammation. They are thus subjected to mechanical forces from sub-msec to several minutes. Complete understanding of the physical processes behind leukocyte adhesion requires an approach over multiple length and time scales, from single protein molecules to the whole cell. This is far from being established due, in part, to the lack of techniques covering the wide range of length and time scales involved. We…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.