ERC Starting Grant · 2018
Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines
A key challenge in biological and soft-matter physics is to identify the principles that govern the organisation and functionality in non-equilibrium systems. Living systems are by definition out of equilibrium and a constant energy input is required to assemble and disassemble the molecular machinery of life. Only out of equilibrium, can proteins assemble to form functional sub-cellular structures, bind cells into dynamic tissues, and form complex biological machines. Our understanding of the physical mechanisms underlying robust protein assembly in driven systems is far from complete. Here I propose to develop a computer-simulation based framework to discover the physical principles of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.