Wolde Lab

Netherlands Foundation of Scientific Research Institutes

West-Nederland (NL3) · Netherlands

ERC-funded
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Research focus

ERC Advanced Grant · 2019

Optimal Cellular Prediction

The ability to respond to changes in the environment is a defining property of life. Strikingly, experiments have vividly demonstrated that even single-celled organisms can leverage correlations in the environmental fluctuations to predict the future environment and mount a response ahead of time. Yet, how reliably single cells can do so and what the fitness benefit of prediction is, are wide-open questions. To predict the future environment, cells need to compress the past signal into the dynamics of the intracellular biochemical network from which the future input is inferred. Yet, storing information is costly while not all features of the past signal are equally informative on the…

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