ERC Consolidator Grant · 2021
Understanding emergent physical properties of chromatin using synthetic nuclei
The main aim of this proposal is to resolve how the physics of molecular-scale activities result in the emergent material properties of chromatin and how those contribute to chromatin organization and function. Mounting evidence suggests that the material properties of chromatin regulate essential nuclear processes. Chromatin has been studied with two disconnected approaches; pure in vitro studies, perfectly suited for careful biophysical measurements on single DNA molecules but lacking the complexity of a cell, or intact cell measurements, with limited access to measure material properties and small-scale chromatin dynamics. The physical properties of chromatin, however, are emergent and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.