Broedersz Lab

Research focus

ERC Consolidator Grant · 2023

Learning the dynamic statistical folding of bacterial chromosomes

The physical organization of bacterial chromosomes is inherently variable, with large conformational fluctuations both from cell to cell and over time. Yet, chromosomes must also be structured to facilitate processes such as transcription, replication, and segregation. A physical description of this dynamic statistical folding of bacterial chromosomes remains largely elusive. Hi-C experiments probe chromosome organization by measuring average contact frequencies of chromosomal loci pairs. Despite the rapidly expanding database of high-resolution Hi-C data for many bacterial species and conditions, these data are still mainly interpreted on a case-by-case basis and with qualitative or…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.