ERC Advanced Grant · 2024
Label-free assembly of RNA-containing viruses, one particle at a time
Self-assembly of individual proteins into a virus is fascinatingly efficient. It is fast and highly accurate, and occurs without an external energy source. While the pre- and post-assembly states are well characterised, the study of assembly itself is notoriously difficult, due to the small (nanometre) size of viral shells and the transient nature of the assembly intermediates. The actual process of virus assembly remains in fact poorly understood. In this project, I focus on the pathogens responsible for the diseases AIDS and COVID-19, the two major pandemics of the last 50 years. The causative agents of these pandemics are the RNA-containing viruses HIV and SARS-CoV-2, respectively. Using…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.