ERC Starting Grant · 2024
Deciphering Neurodegenerative Disease with fast 3D imaging & functional nanoscopy
Neurodegenerative diseases are incurable, progressive brain disorders associated with accumulation of aberrant protein aggregates with severe effects on movement and mental functioning. The mechanism leading to neurotoxicity is far from understood, due to our lack of insight into early processes. Recently, aberrant liquid-liquid phase separation has emerged as a new concept to explain protein aggregation in neurodegenerative disease. Here, I will investigate the biophysical basis of the formation of different material states of aggregates, by capitalizing on my expertise at the interface of single-molecule biophysics and quantitative, high-resolution imaging in cells. I propose to address…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.