ERC Advanced Grant · 2021
ENGINEERING CELLULAR SELF‐ORGANISATION BY CONTROLLING THE IMMUNO-MECHANICAL INTERPLAY
Both scar formation and restitutio ad integrum during bone regeneration rely on cellular self-organisation that involve cell contraction and fibronectin/collagen formation. This early stage of cellular self-organization is later followed by angiogenesis and mineralisation. Scar-free regeneration of physiological tissue homeostasis requires balanced downregulation of early inflammation, however little is understood of the immune-mechanical coupling involved. We aim to lay the foundation for reducing patient suffering resulting from scarring by combining two distinct scientific worlds, for which we have been a major driving force: the distinct regulation of local inflammation and the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.