ERC Starting Grant · 2021
Dissecting Macrophage Mechanobiology to Engineer Immuno-Regenerative Biomaterials
There is an increasing clinical demand for sophisticated medical implants and the scientific field of implant technology is exponentially growing. The main challenge is to harness the immune response to such an implant. In this research we use the immune response to our advantage, by using bioresorbable synthetic biomaterials that are gradually replaced by living tissue inside the body. One of the key immune cells are macrophages, which are the gatekeepers for successful implant integration. Strategies to harness the macrophage response focus on isolated biomaterial design features, such as biochemical or microstructural modifications. One major neglected factor is how macrophages sense and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.