ERC Consolidator Grant · 2023
All life is dependent on enzymatic reactions and functional enzyme cascades have been evolutionary optimized. Yet, introducing “foreign” enzymes into other organisms through genetic engineering often results in reduced or no enzymatic activity. In nature enzymatic activity and efficiency are often enhanced by encapsulation of enzymes in microcompartments resulting in protection and rate enhancement through high local concentrations of enzymes, co-factors and substrates. In NanoCat I will engineer artificial microcompartments hosting highly efficient enzyme cascades that are operational in organisms where they do not naturally occur. The approach is based on my recently developed method to…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.