ERC Consolidator Grant · 2024
Gating cell force sensors with tailor-made nanoswitches to restore tendon tissue function
It’s becoming increasingly clear that a deeper understanding of tendon mechanobiology is required for the development of effective therapies for tendon injuries and diseases. The involvement of specialized cell force sensors, such as PIEZO channels, on the mechanosensory processes through which tendons sense and adapt to mechanical loading have just started to be unveiled. Decoding the underlying mechanisms governing these processes would promote the development of innovative therapies to restore tendon function. However, a remaining barrier to unlock the therapeutic potential of PIEZOs is how to effectively target and gate these complex mechanoreceptors in different tendon cell populations…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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