Saez Lab

Spanish National Research Council (CSIC)

Comunidad de Madrid (ES3) · Spain

ERC-funded
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ERC Consolidator Grant · 2025

In vivo imaging of blood flow dynamics and cell migration in tumour microvasculature via real-time single nanoparticle tracking with positrons

The tumour microvasculature consists of a disorganised network of immature blood vessels with aberrant dynamics and high permeability, which play a critical role in tumour growth, metastasis, and resistance to therapy. Despite its importance, studying blood flow dynamics and cell migration within this environment remains challenging due to the microvasculature's complexity, minute size, and structural irregularities. Positron emission particle tracking (PEPT), a technique that tracks a single particle radiolabelled with a positron emitter in real-time and 3D, offers a transformative solution to investigate such intricate systems. Widely used in industry to study complex flow dynamics,…

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