ERC Starting Grant · 2016
Entrapment of Hypoxic Cancer by Macrophages Loaded with HAP
The proposed project seeks to open a new research front within the field of drug delivery to the solid tumours. Unsatisfactory response of tumours to chemotherapy is mainly related to impaired diffusion of the anticancer drug because of decreased drug uptake due to poor vasculature. Moreover, the drug is not able to penetrate the most hypoxic sites. Cells from these ‘untreated’ sites are responsible for relapse and metastasis. However, these avascular regions attract macrophages that migrate even to areas far away from blood vessels. Therefore, they might constitute a unique delivery system of drug containing particles to these parts of the tumour mass. A promising example of such particles…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.