Gallego Lab

Biomaterials Cooperative Research Centre (CIC biomaGUNE)

Noreste (ES2) · Spain

ERC-funded
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ERC Consolidator Grant · 2018

Artificial metabolic cells for biomanufacturing of bio-based chiral fine chemicals

One of the major challenges of sustainable chemistry is expanding the palette of bio-based chemicals that can replace, or at least ameliorate, the exploitation of fuel-based chemicals. Cell-free metabolic engineering using soluble enzymes is an emerging and versatile approach that seeks to increase the selectivity and productivity of chemical biomanufacturing processes. However, soluble and isolated enzymes present major issues in terms of efficiency, stability and re-usability that hamper industrial applications. To solve these problems, enzymes can be rationally immobilized on smart materials resulting in robust, efficient and self-sufficient heterogeneous biocatalysts, but immobilization…

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