Eyer Lab

Research focus

ERC Starting Grant · 2018

High-throughput single-cell phenotypic analysis of functional antibody repertoires

Antibodies play an important role ensuring successful protection after vaccination. Upon injection, antigen-binding antibodies are generated to prime the host’s immune system for future encounters with the threat. These responses are highly heterogeneous, with each cell contributing with a single antibody variant to the complexity. Each antibody variant furthermore can recognize a different antigen/epitope with varying specificity and affinity. The immunological function induced is related to those parameters. Depending on the nature of the threat, required protective functional antibodies vary. Therefore, also each vaccination against those threads needs to trigger a specific functional…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.