ERC Advanced Grant · 2019
Coenzyme- and metabolite-linked RNAs as a new paradigm in epitranscriptomics
Background: RNA is an important regulator in biology. Recently we discovered the ubiquitous redox coenzyme nicotinamide adenine dinucleotide (NAD) to be attached to bacterial RNAs in a cap-like manner, and to modulate the functions of these RNAs, and others identified NAD-RNAs in eukaryotes. Enzymes were discovered that synthesize or break down NAD-RNAs. Scientific problems: NAD is just one of many coenzymes and metabolic intermediates that carry a nucleotide moiety which is not involved in the catalyzed reaction. Yet, it has been conserved through evolution, a fact that suggests high functional relevance. Hypothesis: The nucleotide moiety in coenzymes and metabolites is there for a reason:…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.