ERC Advanced Grant · 2019
Multiple Designer Organelles for Expanded Eukaryotic life
The emergence of organelles dedicated to specific cellular functions drove the evolution of more complex eukaryotic organisms. We recently created membraneless organelles inside eukaryotic cells dedicated to orthogonal translation, which opened a new path to residue-specific protein engineering using genetic code expansion. We now want to design novel organelles into eukaryotes that will internally enact the entire central dogma of molecular biology. This will supplement the complex eukaryotic cell with an additional simple and easily tailored orthogonal machinery that can also facilitate transcription and replication. This will enable us to create eukaryotes that have more than four…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.