ERC Consolidator Grant · 2019
Physiologically Crowded Artificial Cells for Relevant Drug Screens
In the crowded cell, nonspecific interactions between biomolecules alter biochemical equilibria. This matrix of weak nonspecific interactions is composed of hydrophobic, electrostatic, H-bonding, van der Waals, and steric interactions, and is “the dark matter of biology”. Inaccurate prediction of the behaviour of biomolecules inside cells hampers drug discovery: A high throughput drug screen against a purified target protein in dilute buffer ignores the presence of these weak interactions and results are less relevant. High throughput screens directly in cells are however more difficult to control, interpret and measure. PArtCell provides a key advance by combining the high level of control…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.