Uauy Lab

John Innes Centre - UK

- · United Kingdom

ERC-funded
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ERC Consolidator Grant · 2019

Dominant cis-regulatory variation to improve quantitative traits in polyploid wheat

Urgent action is needed to sustainably intensify global crop production using science-based solutions. Across crops, selection for mutations in cis-regulatory regions of transcription factors has been at the centre of the domestication and breeding process to improve productivity traits. Further efforts to advance towards this goal, however, are hampered in the young polyploid genome of wheat as many genes are present as two or three homoeologous copies with overlapping functions. As a result, recessive variation at single loci is often masked by redundancy with homoeologous copies. This understanding, together with the recent breakthroughs in wheat genomics and gene editing approaches,…

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