Heinis Lab

Research focus

ERC Advanced Grant · 2020

Targeting the "untargetable" by merging biological and chemical compound libraries

Genome sequencing combined with powerful new research technologies has greatly expanded the number of potential drug targets, offering enormous opportunities to address unmet medical needs. However, for proteins with flat, featureless surfaces or for protein-protein interactions, it has been difficult to impossible to generate ligands based on classical small molecules, hindering their evaluation as targets and the development of drugs. Herein, we propose a new method and its application for targeting the so-called "undruggable" proteins by tapping into a new chemical space, generated by "merging" biological and chemical compound libraries. In brief, millions of short cyclic peptides (4–6…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.