ERC Advanced Grant · 2021
Practical oxyfunctionalisation biocatalysts by engineering monooxygenases into peroxyzymes.
Chemistry is far away from being a mature science: many desirable transformations are still out of scope. One important example is the selective (oxy)functionalisation of non-activated C-H bonds, which still represents a dream reaction of organic chemistry. This is because balancing high reactivity (needed for the activation of inert C-H bonds) with selectivity is difficult to achieve. Enzymes, specifically monooxygenases, are catalysts that principally solve this challenge. Monooxygenases, however, are not practical catalysts for organic chemistry. This is because they have evolved to enable the survival of their host organisms and not to suit the needs of organic chemists. In particular…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.