Wierckx Lab

Juelich Research Centre

Nordrhein-Westfalen (DEA) · Germany

ERC-funded
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ERC Consolidator Grant · 2021

Production of a second phase of hydrophobic aromatics with solvent-tolerant Pseudomonas

Replacement of fossil chemicals with biological counterparts has been widely accepted as a vital pursuit to increase the sustainability of our chemical and material industries. Synthetic biology and metabolic engineering enable us to produce a plethora of chemicals with microbes, but the majority of these never make it past the proof-of-principle stage. This is especially the case for drop-in bulk aromatics like styrene or benzene. The main reason for this is that such products are too toxic to ordinary production microbes. In PROSPER I aim to overcome this hurdle and demonstrate the efficient microbial production of hydrophobic aromatic chemicals using solvent-tolerant Pseudomonas. I will…

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