Stael Lab

Swedish University of Agricultural Sciences

Östra Sverige (SE1) · Sweden

ERC-funded
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ERC Consolidator Grant · 2021

Towards increased biosafety for non-target insects - Damage-activated proteolysis to selectively enhance toxicity of pesticides

Insects numbers and diversity have rapidly declined in the EU and worldwide. Pesticides, and particularly the toxicity of insecticides to non-target insects (e.g. bees), are one of the major drivers of insect declines. Apart from destabilizing natural ecosystems, pollinator disappearance directly threatens food security. To help combat insect decline, I propose an innovative approach for the damage-activation of pro-pesticides (DAPP) by plant proteases that are activated in the gut of feeding caterpillars. Non-target beneficial insects that cause no damage, including pollinators and natural enemies of pests, are spared. My team pioneers the study of proteolysis in the plant wound response,…

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