Wieringa Lab

Maastricht University

Zuid-Nederland (NL4) · Netherlands

ERC-funded
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Research focus

ERC Starting Grant · 2021

The biofabrication of a 3D in vitro human oviduct model to study infertility and factors affecting embryo development

Despite being viewed as a simple transport conduit, the oviduct can determine a successful pregnancy and has a life-long impact on our health and wellbeing. Also called the fallopian tube, our understanding of tubal function remains limited, owing to the ethical limitations of human studies and the poor translations of animal studies to people. The objective of the OviChip project is to create the first full-scale 3D in vitro model of the oviduct that can address our knowledge gap. The oviduct selects healthy sperm and hosts the first embryonic cell divisions, setting the stage for fetal development and health in our adult life. Epigenetic factors can trigger genetic defects in these first…

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