ERC Consolidator Grant · 2022
Proton transfer (PT) reactions within proteins are fundamental in biological systems, such as within ATP production. To date, there are no direct means to measure specific PT pathways within proteins, and most research is based on following the end-product of the PT reaction across a natural proton pathway. Here, our goal is to develop a novel way to directly measure PT within proteins. Our new approach is based on placing proton donors and acceptors in specific places within proteins, in which the PT will be initiated only after light excitation of the system. To do so, we introduce here two noncanonical amino acids (ncAA) we developed, with a photoacid and a photobase as their residues…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.