Niederholtmeyer Lab

Technical University of Munich

Bayern (DE2) · Germany

ERC-funded
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Research focus

ERC Starting Grant · 2022

Cell-free synthesis and assembly of biomolecular condensates: Engineering properties, functions and regulation

Compartmentalization is a defining characteristic of life and has the potential to enable and improve engineered manufacturing routes in biotechnology. Many biomolecules like proteins and RNA have the ability to spontaneously cluster in molecularly dense, phase-separated liquid-like assemblies, termed biomolecular condensates. Biomolecular condensates are promising as synthetic compartments in cell-free reactions and living cells because they could provide programmable, self-assembled spatial organization and rapidly appear or dissolve on demand. However, we are still lacking key engineering and characterization tools, a fundamental understanding of how the unique material properties…

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