Oses-Ruiz Lab

Public University of Navarre

Noreste (ES2) · Spain

ERC-funded
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ERC Starting Grant · 2022

Dissecting the molecular mechanisms of cellular heterogeneity controlling infection-associated development in plant pathogenic fungi

Clonal microorganisms display cellular heterogeneity at the transcriptional level, to survive under unfavourable conditions or differentiate into specialised structures. This is the basis of antibiotic and fungicide resistance, but very little is known about how cellular heterogeneity originates and operates in the infection biology of agricultural fungi. Magnaporthe oryzae is one of the most devastating fungal pathogens in the world that destroys enough rice to feed 60M people every year. It produces ~50,000 new spores a day from a single lesion in the fields, but it remains unknown whether they are transcriptionally different. Spores contain three cells that display cellular heterogeneity…

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