ERC Advanced Grant · 2023
Intramer-mediated multi-parallel mapping of signalling pathways
Cellular behaviour is methodically studied using systems biology approaches that analyse the presence, absence, or oscillation of biomolecules. To this end, exogenous perturbations, among others, are used to alter protein expression and study their effects on cellular homeostasis. However, proteomes are inherently versatile and diversified by alternative splicing, protein cleavage, and post-translational modifications (PTM). Similarly, the spatiotemporal formation of multicomponent complexes plays an important but less well understood role in cellular homoeostasis and disorders. Specific recognition of these complexes by ligands is a difficult task to solve. Therefore, deciphering…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.