ERC Consolidator Grant · 2023
Improving plant immunity by synthetic exploitation of the ubiquitin system
Plants are continuously attacked by pathogens and pests, resulting globally in large agricultural losses and food insecurity at high economic cost. To counter infection, plants have developed sophisticated immune responses in which the post-translational modifier, ubiquitin, plays indispensable roles. Ubiquitination is a versatile protein modification that regulates the amplitude and intensity of immune responses, thereby establishing durable resistance. Substrate ubiquitination is performed by E3 ligases that act as matchmakers by recruiting specific substrates. Despite the essential roles of E3 ligases in plant immunity, it remains unclear how they achieve such extraordinary substrate…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.