ERC Consolidator Grant · 2023
RNA-based gene writing in human cells
CRISPR development has enormously accelerated genetic engineering principles, and precise methods to modify small alleles (such as base or prime editing) are now available. However, generating large genomic changes still presents enormous challenges. Large modifications, such as gene transfers, are performed generally with viral vectors, which have been associated with toxicities in the clinic, and often lack versatility needed for basic science experimentation. Newer CRISPR-based techniques for gene transfer suffer from significant efficacy and safety problems when used for large message writing. The overall goal of SCRIBE is to create new strategies for gene writing and define their…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.