Valgepea Lab

University of Tartu

Eesti (EE0) · Estonia

ERC-funded
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ERC Consolidator Grant · 2023

Next-generation engineering of gas-fermenting cell factories through large-scale systems-level maps

Gas fermentation provides a unique opportunity for the circular bioeconomy by enabling carbon recycling from gaseous waste feedstocks into value-added bioproducts using microbes. Acetogens are ideal biocatalysts for gas fermentation as they use gas (CO and/or CO2+H2) as their sole carbon and energy source, evidenced by the commercialisation of the waste gas-to-ethanol conversion process. Despite recent efforts, our understanding of genotype-phenotype relationships in acetogens is still minimal. This, however, is required for rational metabolic engineering and expanding the product spectrum of acetogens to unlock their full potential. GENESYS aims to engineer superior gas-fermenting cell…

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