ERC Consolidator Grant · 2023
Learning the interaction rules of antibody-antigen binding
Antibody-antigen binding is the basis of two fundamental biotherapeutic pillars: monoclonal antibodies (1) and vaccines (2). To accelerate therapeutics discovery, we need to perform antibody (Ab) and antigen (Ag) design in silico. Specifically, we need to address a fundamental immuno-biotechnological challenge: understanding the interaction rules that predict Ab-Ag binding. Solving this challenge demands the convergence of biotechnology, computational structural biology, and machine learning (ML). My lab is one of the few worldwide to have this transdisciplinary expertise. Research problem: Currently, the predictive performance of Ab-Ag binding is poor, and an understanding of the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.