Rems Lab

University of Ljubljana

Slovenija (SI0) · Slovenia

ERC-funded
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Research focus

ERC Starting Grant · 2023

Reversible and irreversible cardiac electroporation: Establishing the fundamentals to advance cardiac treatments

Cardiovascular diseases are the No. 1 healthcare challenge in the world, among which ischemic heart disease and atrial fibrillation are the most prevalent. Better treatment strategies are greatly needed to reduce the medical, economic, and social burden of these conditions. Electroporation (application of intense pulsed electric field) is showing tremendous potential for treatment of atrial fibrillation, enabling a safer and shorter treatment procedure compared with existing thermal ablation approaches. Moreover, recent pioneering studies provide evidence that electroporation can also be used as a nonviral vector for intracellular delivery of therapeutic nucleic acids that promote cardiac…

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