Jeschke Lab

Research focus

ERC Starting Grant · 2023

Exposing hidden targets of drug resistance in cancer by mapping the epitranscriptome at single-cell resolution

Drug resistance is one of the biggest challenges in the clinical management of breast cancer (BC), but the underlying mechanisms are still not fully understood. What we do know is that epigenetic mechanisms play a key role in the adaptation of cancer cells to therapy, which is why they have become a prime field of investigation. Single-cell profiling of epigenetic DNA and histone modifications have already revealed intriguing and actionable insights into tumor heterogeneity. For the most recently discovered epigenetic layer however, which consists of RNA modifications, we have not yet reached single-cell resolution. The exciting potential of RNA modifications to fine-tune the processing and…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.