ERC Advanced Grant · 2024
Guidance of axonal pathfinding via nano-switches
Axon navigation is guided by spatial patterns of chemical and physical cues in the developing brain. After a damage, the pattern is lost. Axons do not have instructions to reach their target. Axon regeneration, if stimulated, occurs by chance. Unfortunately, current technologies do not allow us to control axon navigation decisions, and guided re-innervation is not possible in the central nervous system (CNS). The GAP project aims to fill this knowledge gap by modulating neuron mechanotransduction, in order to program axon pathfinding and to differentiate axon navigation decisions. Cells will be engineered to express magnetic nano-switches that can generate forces in specific nano/micro…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.