ERC Consolidator Grant · 2024
Biomolecular regulation with interlocked cyclic oligonucleotides
Developing molecules that display protein-like functions and efficiently operate in complex biological environments, e.g. cells, is a grand challenge in chemistry. The aim of BioRIcON is to develop a novel class of biohybrid interlocked molecules (BIMs) that mirrors the function of proteins and enables precise biomolecular regulation. Despite the advances of interlocked molecules, often compared to biological motors, their use in cellular or in vivo settings pales compared to their natural counterparts. BioRIcON comprises an entirely new concept in artificial biology and biomolecular control by yielding BIMs that contain dynamic components ultimately designed to efficiently actuate in cells…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.