Claassens Lab

Wageningen University

Oost-Nederland (NL2) · Netherlands

ERC-funded
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ERC Starting Grant · 2024

Systematic analyses and rational engineering of fast CO2 fixation pathways in living cells

Biological CO2 fixation is the primary process responsible for biomass and food production and a key player in the atmospheric CO2 balance. Almost all biological CO2 fixation is caried out by a single pathway: the Calvin cycle. Despite the dominance of this pathway in nature it seems relatively inefficient due to high energy costs and poor enzyme kinetics. An exciting option to improve this efficiency, is the exploration of potentially more efficient synthetic CO2 pathways. However, a key challenge to identify promising synthetic CO2 fixation pathways is the limited availability of kinetic data on relevant enzymes. In addition, kinetic data are usually measured in vitro and hence not always…

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