ERC Consolidator Grant · 2025
In TeaM I propose a synthetic biology-based multi-cellular strategy to fight solid tumors, addressing the immunosuppressive tumour microenvironment (TME). WHY: Synthetic biology is transforming cell-based immunotherapies with control circuits in immune cells like T cells and macrophages. However, in solid tumours the TME renders these cells dysfunctional, limiting their efficacy. Innovative solutions are needed to address this unmet need and unlock the full potential of immunotherapies. WHAT: TeaM integrates synthetic biology, immunology, and artificial intelligence to arm CD8+T cells and macrophages with synthetic communication systems that sense the immunosuppressive TME and activate…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.