Platt Lab

Research focus

ERC Consolidator Grant · 2025

Proteome-scale programmable protein perturbation and induced proximity

Programmable perturbation technologies such as CRISPR-Cas have transformed how we study biological systems by offering efficient and scalable methods to manipulate DNA and RNA, thereby linking genotype to phenotype. However, corresponding technologies for rationally manipulating all proteins have lagged behind, restricting our ability to connect proteotypes to phenotypes. Developing a programmable protein perturbation technology would be a breakthrough in the biomedical sciences, as it would facilitate the interrogation of biology and creation of medicines in fundamentally new ways. The overarching goal of this proposal is to develop and apply such a high-throughput programmable protein…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.