Tang Lab

Research focus

ERC Consolidator Grant · 2025

Mechanical sensing and reprogramming of CAR-engineered lymphocytes for next-generation ACT cancer immunotherapy

Adoptive cell transfer (ACT) with cytotoxic lymphocytes, including chimeric antigen receptor (CAR)-T cells, is a powerful immunotherapy already demonstrating remarkable success against certain blood cancers. However, its efficacy in treating solid tumors remains limited, with durable responses being rare. Current strategies to improve ACT therapy focus predominantly on biochemical interactions between immune cells and cancer cells. Yet, emerging evidence highlights the significant influence of biomechanical cues in shaping immune responses and therapeutic outcomes. For instance, the mechanical properties of cancer cells, such as cellular softness, can confer resistance to immune…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.