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ERC Starting Grant · 2025

Remote control of multiple cell functions through multi-stimuli-responsive nanoparticle assemblies

CELL-NANO-REMOTE aims to achieve flexible, remote control over therapeutic cell behaviour. In previous work in optogenetics and magnetogenetics, only partial remote cell control has been attained using light or magnetic fields as triggers. Furthermore, these approaches are generally limited to single cell responses, typically influencing one particular gene, receptor, or ion channel. In contrast, CELL-NANO-REMOTE seeks to obtain independent control over various cell functions without cross-activation upon application of external stimuli (light, magnetic fields or ultrasound). To surpass the limitations of current strategies and achieve the ambitious goal of the project, CELL-NANO-REMOTE…

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