Atkins Lab

University of Edinburgh

- · United Kingdom

ERC-funded
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Research focus

ERC Starting Grant · 2017

HIV-1 acquisition and the future of prevention strategies: deciphering the eclipse phase through modelling and phylogenetics

The HIV eclipse phase typically refers to the time between a virus entering a sexually exposed person and detection of viral RNA in their plasma. Of the four phases of HIV-1 infection (eclipse, acute, chronic and AIDS), the eclipse phase is currently the only window of opportunity for viral clearance. Systemic infection is currently irreversible after the onset of the acute phase. Preventing systemic HIV infection after exposure, therefore, requires understanding and targeting the eclipse phase. Information on this phase, however, is partial and indirect, with fundamental gaps in our knowledge of its role in limiting transmission, in determining the efficacy of infection control strategies,…

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