Mizrahi Lab

Ben-Gurion University of the Negev

- · Israel

ERC-funded
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ERC Consolidator Grant · 2019

Reducing rumen complexity to its essential components to understand and modulate ecosystem structure and function

Ruminants represent a paradigmatic case of obligatory host-microbiome relationships. These animals require complex microbial communities to digest plant fibers. Which functions are essential and how the assembly of these functions impacts host physiology remain unknown. My goal is to understand the underlying aspects that allow the host and its microbes to coexist and to identify the essential requirements of this microbial community to sustain the life of the host. This proposal aims to address this ambitious and fundamental challenge. These efforts build on a unique research platform involving germ-free ruminant animals, modeling, genomics, metabolomics, as well as animal and microbial…

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