Moran Lab

Hebrew University of Jerusalem

- · Israel

ERC-funded
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ERC Consolidator Grant · 2019

Unravelling the evolution of antiviral sensors and response systems in animals using the phylum Cnidaria

Viruses are absolute parasites as their replication depends on biochemical systems of their host. Because viral infections reduce the fitness of the host organism, hosts and viruses have been tangled in an evolutionary arms race for survival from the very beginning of life. As the immune system allows organisms to identify and eliminate viral infections, it is of pivotal importance for host fitness. In vertebrates, the antiviral immunity is heavily based on the interferon pathway that enables infected cells to alert neighbouring cells against incoming infection and recruits cells of the immune system to battle the virus. However, in the case of invertebrates, which lack interferons, the…

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